The skin is colonized by a vast terrain of microorganisms, bacteria and, to a lesser extent, fungi and viruses that comprise the ecological community of the human microbiome. The microbiome nexus places emphasis primarily on human health; however, a broadened perspective also reflects the interaction between the microbiota, external influences, and the skin's barrier. The homeostasis of the skin’s microbiome and skin barrier is strongly influenced by lifestyle, host factors and the exposome. This formidable complex system is composed of integrative microorganisms involving both the skin and the gut, each having essential protective functions against invading pathogens, mediating inflammatory conditions, and modulation of the immune system. This unique symbiotic network provides cell-to-cell communications, and integral lipid components and functions as a gateway between external and internal environments.
This lecture will explore several intrinsic and extrinsic aspects of the skin’s microbiome, and the microbiome's relationship with the skin barrier.
LEARNING OBJECTIVES: - Identify the functions of the skin microbiome and the immunity of the skin's barrier.
- Illustrate the key objectives of the microbiome's habitat and its relationship with the skin barrier.
- Identify obstacles that hinder barrier function and its impact on the microbiome and skin physiology.
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